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6S)-4-(dimethylamino)-5-hydroxy-6-{[(4R
and AKTThr308 while having no direct effect on VEGFR phosphorylation
Solubility: DMSO : ≥ 38 mg/mL (115
In kinetic experiments with kainate as the agonist
Bafilomycin A1 at a low concentration (1 nM) effectively and specifically inhibits and kills pediatric B-cell acute lymphoblastic leukemia cells
HQ-415 Catalog No.:M25075-C 6S)-4-(dimethylamino)-5-hydroxy-6-{[(4RHQ 415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting a EC50 for HQ 415 is 15 M. IC50 value: 15 M (EC50)in vitro: In TDP 43 expressing cells, CQ fails to synergize with HQ 161 and actually antagonizes HQ 161 rescuing activity. In contrast, despite the fact that CQ was completely inactive against TDP 43, it strongly synergized with HQ 415, decreasing the EC50 from 16 to 5 M. HQ